There was extensive variation in mortality between the 19 hospitals in the study, ranging from 1.6% to 27.3%, with markedly higher rates in LMICs. Newborn babies are particularly at risk of severe infection because of their underdeveloped immune systems. Every year, 214,000 newborn babies, mostly in low- and middle-income countries (LMICs), die of sepsis that has become resistant to antibiotics. Sepsis is a life-threatening bloodstream infection which affects up to 3 million babies a year globally. The study has given us vital information which will help us to better design clinical trials and ultimately improve the care and outcome of babies with neonatal sepsis,” said Manica Balasegaram, Executive Director of GARDP. “It was very important to undertake this study to get a better understanding of the kind of infections we’re seeing in newborns in hospitals, the bugs causing them, the treatments that are being used and why we are seeing more deaths. The study was conducted by the Global Antibiotic Research and Development Partnership (GARDP) in collaboration with St George’s, University of London (SGUL) Penta – Child Health Research the Medical Research Council Clinical Trials Unit at University College London (MRC CTU at UCL), whose research team led in analyzing the data and the University of Antwerp. The findings of the observational study have been published in a paper in PLOS Medicine co-authored by a global team of over 80 researchers spanning four continents.
The study has provided a wealth of high-quality data aimed at improving the treatment of newborn babies with sepsis. The study, conducted from 2018 to 2020, found there was high mortality among infants with culture-positive sepsis (almost 1 in 5 across the hospital sites), and a significant burden of antibiotic resistance. Geneva - A global observational study, which involved more than 3,200 newborn babies suffering from sepsis in 19 hospitals in 11 countries, has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness.
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